Corticosteroid myopathy presents as weakness and wasting of the proximal limb and girdle muscles and is generally reversible following cessation of therapy.
Corticosteroids inhibit intestinal calcium absorption and increase urinary calcium excretion leading to bone resorption and bone loss. Bone loss of 3% over one year has been demonstrated with prednisolone 10 mg per day. Postmenopausal females are particularly at risk for loss of bone density. Sixteen percent of elderly patients treated with corticosteroids for 5 years may experience vertebral compression fractures. One author reported measurable bone loss over two years in women on concomitant therapy with prednisolone mg per day and tamoxifen. [ Ref ]
The typical thinning of vulvar skin also improves with treatment but the lightening of the skin may remain even with good treatment. Side effects are uncommon and will be checked for by your daughter’s clinician with regular follow-up. Non-steroid topical medications are being studied for the treatment of lichen sclerosus and may hold promise as a way of treating lichen sclerosus without the potential side effects of topical steroids. Other topical and/or oral medicines may be recommended if your daughter’s clinician suspects she also has a vulvar skin infection (such as a bacterial, fungal, or viral infection) or a local allergic reaction.
Silicones have been used since the 1960’s in burn centers and hospitals. Only the last decades they have become available on the consumer market. Many people are still not aware of the existence (let alone effectiveness) of silicone sheeting for scars. Among those who are unaware of the benefits of silicones are not only consumers but also medical personnel. It’s a sad fact that many doctors, but even dermatologists, and plastic and cosmetic surgeons are not aware of the clinical proof that backs the use of silicones for scars.