Glucocorticoids such as prednisolone cause profound and varied metabolic effects. In addition, they modify the body's immune responses to diverse stimuli. Medication Guide
Prednisolone Acetate Ophthalmic Suspension USP 1%
FOR TOPICAL OPHTHALMIC USE ONLY.
INGREDIENTS: Each mL contains:
Active: prednisolone acetate %.
Preservative: benzalkonium chloride %.
Inactives: dibasic sodium phosphate, polysorbate 80, edetate disodium, glycerin, citric acid and/or sodium hydroxide (to adjust pH), purified water.
USUAL DOSAGE: Two drops topically in the eye(s) four times daily.
WARNING: Do not touch dropper tip to any surface, as this may contaminate the suspension.
Read enclosed insert.
SHAKE WELL BEFORE USING.
STORAGE: STORE UPRIGHT at 8° - 24°C (46° - 75° F).
Alcon Laboratories, Inc.
Fort Worth, Texas 76134 for
Princeton, NJ 08540
Printed in USA
As a glucocorticoid , the lipophilic structure of prednisolone allows for easy passage through the cell membrane where it then binds to its respective glucocorticoid receptor (GCR) located in the cytoplasm. Upon binding, formation of the GC/GCR complex causes dissociation of chaperone proteins from the glucocorticoid receptor enabling the GC/GCR complex to translocate inside the nucleus. This process occurs within 20 minutes of binding. Once inside the nucleus, the homodimer GC/GCR complex binds to specific DNA binding-sites known as glucocorticoid response elements (GREs) resulting in gene expression or inhibition. Complex binding to positive GREs leads to synthesis of anti-inflammatory proteins while binding to negative GREs block the transcription of inflammatory genes.