Potency of ophthalmic steroids

Microbiology: The anti-infective components in CORTISPORIN Ophthalmic Ointment are included to provide action against specific organisms susceptible to it. Neomycin sulfate and polymyxin B sulfate are active in vitro against susceptible strains of the following microorganisms: Staphylococcus aureus, streptococci including Streptococcus pneumoniae , Escherichia coli , Haemophilus influenzae, Klebsiella/Enterobacter species, Neisseria species, and Pseudomonas aeruginosa . The product does not provide adequate coverage against Serratia marcescens (see INDICATIONS ).

The pH of the vancomycin solutions suspended in BSS ® was closer to neutral compared with those recorded with other solvents ( Arıcı et al. 1999 ; Lin et al. 2005 ), thus rendering vancomycin less irritating for eyedrop use. Over time, the pH showed a slight but steady tendency to increase, which was more prominent in the solutions exposed to light at 24 °C. Vancomycin suspensions in water for injection and in % NaCl are more acidic than suspensions in BSS ® ( Arıcı et al. 1999 ; Lin et al. 2005 ). No significant changes were observed regarding the antibacterial potency of vancomycin over time, indicating that suspensions of vancomycin in BSS ® remained stable throughout the study period, irrespective of temperature and light storage conditions.

Topical antibiotics, particularly, neomycin sulfate, may cause cutaneous sensitization. A precise incidence of hypersensitivity reactions (primarily skin rash) due to topical antibiotics is not known. The manifestations of sensitization to topical antibiotics are usually itching, reddening, and edema of the conjunctiva and eyelid. A sensitization reaction may manifest simply as a failure to heal. During long-term use of topical antibiotic products, periodic examination for such signs is advisable, and the patient should be told to discontinue the product if they are observed. Symptoms usually subside quickly on withdrawing the medication. Application of products containing these ingredients should be avoided for the patient thereafter (see PRECAUTIONS: General ).

Potency of ophthalmic steroids

potency of ophthalmic steroids


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