January 9, 2009 – Early in the morning, I go to Emory Johns Creek Hospital to get the CT scan. It is uneventful, as radiology appointments typically are, and I go home. We are having a houseful of people that night for a neighborhood party and there is a lot to do. Two hours later, a nurse calls from Dr. Gupta’s office and says he would like me to come in as soon as possible so he can discuss the CT results with me. I am annoyed by this, but still mindful that if a doctor wants to talk “right away,” then I should probably go.
Terminal prostaglandin synthases have been identified that are responsible for the formation of other prostaglandins. For example, hematopoietic and lipocalin prostaglandin D synthases (hPGDS and lPGDS) are responsible for the formation of PGD 2 from PGH 2 . Similarly, prostacyclin (PGI 2 ) synthase (PGIS) converts PGH 2 into PGI 2 . A thromboxane synthase ( TxAS ) has also been identified. Prostaglandin-F synthase (PGFS) catalyzes the formation of 9α,11β-PGF 2α,β from PGD 2 and PGF 2α from PGH 2 in the presence of NADPH. This enzyme has recently been crystallized in complex with PGD 2  and bimatoprost  (a synthetic analogue of PGF 2α ).